Fig. 2: Single-cell RNA sequencing analysis of integrated NSCLC data reveals MZT2B enrichment in malignant epithelial cells and associated functional pathways. | Cell Death & Disease

Fig. 2: Single-cell RNA sequencing analysis of integrated NSCLC data reveals MZT2B enrichment in malignant epithelial cells and associated functional pathways.

From: MZT2B promotes malignant phenotypes in NSCLC cells by enhancing mitochondrial function and COX5B expression

Fig. 2

UMAP (uniform manifold approximation and projection) visualization of integrated single-cell lung cancer data, colored by cell type annotations provided by original authors (A). UMAP visualization of integrated single-cell lung cancer data, colored by original data source (B). UMAP visualization showing the expression density of MZT2B across all integrated cells (C). Dot plot illustrating the percentage of cells expressing MZT2B and average expression levels across different cell types in both LUAD and LUSC, highlighting predominant MZT2B expression in malignant epithelial cells and higher expression in LUSC (D). UMAP visualization of re-clustered malignant cell populations from integrated lung cancer data, colored by sub-cluster identity (E). Dot plot displaying the percentage of cells expressing MZT2B and average expression levels across different malignant cell sub-clusters, demonstrating high MZT2B expression in proliferating cancer cell subsets (F). Correlation analysis of MZT2B with other genes within cancer cell subpopulations, showing the top 100 positively correlated genes (G). Bar plot depicting enriched Gene Ontology (GO) biological processes for genes positively correlated with MZT2B expression (H). Bar plot illustrating enriched WikiPathways for genes positively correlated with MZT2B expression (I).

Back to article page