Fig. 3: MZT2B is consistently overexpressed in malignant epithelial cells across primary and metastatic sites in lung adenocarcinoma (LUAD). | Cell Death & Disease

Fig. 3: MZT2B is consistently overexpressed in malignant epithelial cells across primary and metastatic sites in lung adenocarcinoma (LUAD).

From: MZT2B promotes malignant phenotypes in NSCLC cells by enhancing mitochondrial function and COX5B expression

Fig. 3: MZT2B is consistently overexpressed in malignant epithelial cells across primary and metastatic sites in lung adenocarcinoma (LUAD).

UMAP visualization of primary LUAD tumor single-cell data, colored by cell type annotations (A). Dot plot depicting the percentage of cells expressing MZT2B and average expression levels across different cell types in primary LUAD tumors, highlighting high MZT2B expression in malignant epithelial cells (B). UMAP visualization of LUAD brain metastases single-cell data, colored by cell type annotations (C). Dot plot showing MZT2B expression in different cell types within LUAD brain metastases (D). UMAP visualization of LUAD lymph node single-cell data, colored by cell type annotations (E). Dot plot illustrating MZT2B expression in different cell types within LUAD lymph node samples, with notable enrichment in malignant epithelial cells of metastatic lymph nodes (mLN) compared to non-metastatic lymph nodes (nLN) (F). UMAP visualization of LUAD pleural fluid single-cell data, colored by cell type annotations (G). Dot plot highlighting MZT2B expression in different cell types within LUAD pleural (PE) fluid samples (H).

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