Fig. 8: TDN-LC4 targeting SNX3 ameliorated pulmonary dysfunction and fibrosis.
From: Targeting sorting nexin 3 to treat pulmonary fibrosis by dual modulating Wnt/β-catenin signaling
A Snx3-cTg mice and N-Tg mice were administered BLM and TDN-LC4 at the same time for 3 weeks, with pirfenidone (PFD) as a positive control treatment. B Micro-CT revealed the fibrotic area of the lung tissues; n = 6 mice. C, D HE staining and PSR staining analysis were shown; Scale bar: 200 μm, n = 8 mice. E, F Representative images of IHC staining analysis for SNX3 and β-catenin as indicated (Scale bar: 200 μm; n = 8 mice). The data were shown as means ± SEM. *P < 0.05 vs. Saline. #P < 0.05 vs BLM + LC4 group or sh-NC + TGF-β1. &P < 0.05 vs Snx3-cTg + BLM group. ns, not significant.
