Fig. 8: Lower-weight individuals are more likely to have haematopoietic damage after pelvic radiotherapy. | Cell Death & Disease

Fig. 8: Lower-weight individuals are more likely to have haematopoietic damage after pelvic radiotherapy.

From: Post-irradiation dietary restriction impairs hematopoiesis via inhibition of the pentose phosphate pathway in hematopoietic stem and progenitor cells

Fig. 8

Height and weight were measured weekly in 101 patients undergoing pelvic radiotherapy, and BMI was calculated by taking the mean of the BMI values of the same patient. The values of PB neutrophil, WBC, lymphocyte, RBC, and platelet counts of the patients were recorded weekly for one month after radiotherapy. A Those with a WBC count ≤2 × 103/μL had a smaller BMI than those with a WBC count >2 × 103/μL. B Those with neutrophil deficiencies of grade 3–4 have a smaller BMI than those with neutrophil deficiencies less than grade 3. C Those with a lymphocyte count ≤0.8 × 103/μL had a smaller BMI than those with a lymphocyte count >0.8 × 103/μL. D There was no difference in BMI between those with RBC counts less than or equal to normal and those with RBC counts greater than normal. E There was no difference in BMI between those with platelet counts ≤100 × 103/μL and those with platelet counts >100 × 103/μL. F ROC curves of PB WBCs, neutrophils, and lymphocytes according to the BMI values corresponding to the above groupings. G There is no difference in dose to the BM between patients with high and low BMI. Results were displayed as mean ± SD. ns, not significant; *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001 by unpaired two-tailed Student’s t test. BMI: body mass index.

Back to article page