Fig. 4: CREB3L2 modulates fatty acid metabolism pathways. | Cell Death & Disease

Fig. 4: CREB3L2 modulates fatty acid metabolism pathways.

From: Targeting CREB3L2-mediated lipid metabolism overcomes lenvatinib resistance and attenuates the progression of hepatocellular carcinoma

Fig. 4

A Volcano plot showing differentially expressed genes in 97H cells comparing shNC and shCREB3L2 groups. B, C Differentially expressed genes were conducted to KEGG pathway analysis and GSEA enrichment analysis. D Modulation of oleic acid levels in 97H and Huh7 cells upon CREB3L2 knockdown or overexpression. E, F Determine the levels of triglycerides and cholesterol in 97H and Huh7 cells. G Correlation analysis reveals the relationship between CREB3L2 and the expression of lipid metabolism regulatory molecules. H Correlation analysis of CREB3L2 expression with the expression of FASN, ACC1, ACLY, and SCD1 in the TCGA database. I, J After knocking down or overexpressing CREB3L2, assess the alteration of FASN, ACC1, ACLY, and SCD1. *P < 0.05; **P < 0.01; ***P < 0.001.

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