Fig. 1: Identification of TRIM3 as a target for the interferon-stimulated response in NSCLC.
From: The TRIM3/TLR3 axis overrides IFN-β feedback inhibition to suppress NSCLC progression
A Venn diagram illustrating the intersection of the top 500 DEGs from GSE226667 with 655 known ubiquitin‒proteasome system (UPS) genes. B Volcano plot showing DEGs from the GSE226667 dataset. C Box plot analysis of TRIM3 mRNA levels across cancers from the TCGA database. D Box plot showing changes of TRIM3 mRNA expression in mouse tumor models treated with PD-1, PD-L1 and CTLA-4 inhibitors. E Box plot showing changes in TRIM3 mRNA expression in mouse tumor models following cytokine treatment. *p < 0.05; **p < 0.01; ***p < 0.001.
