Fig. 1: The expression, clinical and prognostic characteristics of CSNK1D in head and neck cancer.

a The schematic representation of TMT-proteomics analysis of three paired oral squamous cell carcinoma (HNSCC) tissues and normal tissues. b Volcano plot of the differentially expressed genes (DECs) in three paired HNSCC tissues (|FC| > 1.2 and P < 0.05). c Comparison of the 17 upregulated genes that were detected in five groups of HNSCC cell lines and HOK by qRT-PCR. CSNK1D had the highest relative expression. d qRT-PCR analysis of CSNK1D expression in 111 paired HNSCC tissues and normal tissues. Comparison of CSNK1D expression in human HNSCC tissue samples and matched non-neoplastic tissue in Gene Expression Omnibus (GEO) datasets GSE74530 and GSE78060. e The CSNK1D expression disparity in HNSCC with different clinical traits in 111 paired HNSCC tissues and normal tissues. f Kaplan–Meier plots of the survival time in The Cancer Genome Atlas (TCGA) HNSCC cohort of patients (n = 520) with high vs low expression of CSNK1D in the primary tumor (segregated using median expression level as cut-off value). g Schematic diagram indicating the construction of a mouse HNSCC model fed with 4NQO and images of immunohistochemical samples. Representative IHC staining images of CSNK1D in human and mouse normal mucosa, atypical hyperplasia and HNSCC tissues (scale bar, 50 μm). IHC immunohistochemistry, HNSCC Head and neck squamous cell carcinoma.