Fig. 5: Increased B lymphocyte infiltration was confirmed in the tumors of Csde1-KO mice. | Cell Death & Disease

Fig. 5: Increased B lymphocyte infiltration was confirmed in the tumors of Csde1-KO mice.

From: CSDE1 depletion inhibits tumor progression through enhancing B-cell infiltration in NSCLC

Fig. 5: Increased B lymphocyte infiltration was confirmed in the tumors of Csde1-KO mice.The alternative text for this image may have been generated using AI.

A–E Flow cytometry analysis of B lymphocytes, DCs, NK cells, macrophages and T lymphocytes from tumor tissues. Representative images and quantification are shown (n = 4). F Multiplex immunohistochemistry analysis of tumor-infiltrating immune cells, including CD19+ B cells, CD3+ T cells, CD4+ T cells, and CD8+ T cells, from tumor tissue. Representative images are shown. G Distance from B cells to CD4+ T cells and CD8+ T cells within a range of 500 μm in tumor tissues from the Csde1-WT and Csde1-KO mice (n = 3). H Counts of CD4+ T cells or CD8+ T cells around B cells within a range of 100 μm in tumor tissues from the Csde1-WT and Csde1-KO mice (n = 3). I Immunohistochemical analysis of the CD19 level in tumor tissues. Representative images and quantification are shown (n = 4). The data represent the mean ± SEM of three independent experiments, *P < 0.05, **P < 0.01, ***P < 0.001.

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