Fig. 1: AQB and CBPt synergistically inhibit EC cell proliferation. | Cell Death & Disease

Fig. 1: AQB and CBPt synergistically inhibit EC cell proliferation.

From: AQB improves carboplatin sensitivity in endometrial cancer through dual DNA repair modulation: suppression of the p21-E2F1-RAD51 and ATF3-HDAC1-BRCA1 signaling

Fig. 1

A Molecular modeling of HOTAIR-EZH2 interaction and structural simulation of drug AQB. B, C Expression levels of HOTAIR and EZH2 in EC patients grouped by clinical stages (Stage I&II vs. Stage III&IV). D Correlation analysis between HOTAIR and EZH2 expression in EC patients, with (E) showing the correlation in advanced-stage EC patients (Stage III&IV). F KEGG analysis of DEGs between AQB and control groups. G Heatmap showing platinum drug resistance-related genes after AQB treatment. H Combination matrices of cell inhibition and synergy scores by AQB and CBPt. Data represent the mean of 3 independent experiments. I IC50 of CBPt after treatment with AQB. The data were expressed as the mean ± SD (n = 3). *P <0.05, **P < 0.01.

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