Fig. 6: AQB enhances CBPt sensitivity in vivo. | Cell Death & Disease

Fig. 6: AQB enhances CBPt sensitivity in vivo.

From: AQB improves carboplatin sensitivity in endometrial cancer through dual DNA repair modulation: suppression of the p21-E2F1-RAD51 and ATF3-HDAC1-BRCA1 signaling

Fig. 6

A Tumor-bearing nude mice were treated with DMSO, AQB (50 mg/kg), CBPt (50 mg/kg), or AQB (50 mg/kg) + CBPt (50 mg/kg) by intraperitoneal injection (Created with bioRender.com). B Image of mice after subcutaneous implantation of HEC-1B cells (n = 6 per group). C Excised tumors from each group. D Tumor volume changes over time(days). E Tumor weights at the end of treatment. F IHC staining for Ki67, RAD51 and BRCA1 in tumor tissues. Scale bars:100 μm. G IF staining of γ-H2AX and cleaved caspase3 in tumor tissues. Scale bars:50 μm. Data are expressed as mean ± SD (n = 6 mice). **P < 0.01, ****P < 0.0001.

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