Fig. 7: AQB enhances CBPt sensitivity and reduces myelosuppression. | Cell Death & Disease

Fig. 7: AQB enhances CBPt sensitivity and reduces myelosuppression.

From: AQB improves carboplatin sensitivity in endometrial cancer through dual DNA repair modulation: suppression of the p21-E2F1-RAD51 and ATF3-HDAC1-BRCA1 signaling

Fig. 7

A Image of mice after subcutaneous implantation of HEC-1B cells (n = 6 per group). Tumor-bearing nude mice were treated with DMSO, CBPt(50 mg/kg) or AQB (50 mg/kg) + CBPt (25 mg/kg). B Excised tumors from each group. C Tumor volume changes over time. D Tumor weights at the end of treatment. E IHC staining for Ki67 in tumor tissues. Scale bars, 100 μm. F PDX models were established from stage IV EC patient tissues. Mice were randomly divided into 3 groups: DMSO, CBPt (50 mg/kg), or AQB (50 mg/kg) + CBPt (25 mg/kg) (Created with bioRender.com). G H&E-stained section of a PDX mouse tumor derived from an EC patient’s primary tumor sample and the original tumor sample from patient. H Excised tumors from each group. I Tumor volume changes over time. J Tumor weights at the end of treatment. K WBC, L NEU, and M PLT levels during treatment. Data are expressed as mean ± SD (n = 6 nude mice, n = 3 C-NKG mice) *P < 0.05, ***P < 0.001, ****P < 0.0001, ns not significant.

Back to article page