Fig. 6: Schematic representation of neutrophil and macrophage cell death under homeostatic and Salmonella Typhimurium (ST) infection conditions. | Cell Death & Disease

Fig. 6: Schematic representation of neutrophil and macrophage cell death under homeostatic and Salmonella Typhimurium (ST) infection conditions.

From: Programmed cell death pathways coordinate neutrophil and macrophage clearance in zebrafish and are differentially exploited by Salmonella Typhimurium

Fig. 6

Under homeostatic conditions, neutrophils and macrophages undergo turnover through regulated cell death mechanisms, including apoptosis, pyroptosis, and necroptosis. Initially, upon S. Typhimurium infection, there is a rapid increase in neutrophil and macrophage numbers due to emergency hematopoiesis. However, as early as 3 h post-infection, neutrophils begin to undergo all three types of cell death: apoptosis, pyroptosis, and necroptosis, while macrophages predominantly die via necroptosis. This shift highlights the dynamic and differential regulation of phagocyte cell death in response to bacterial infection.

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