Fig. 6: PRPF40B modulates NTRK2 splicing to regulate TRKB-FL expression during differentiation in SH-SY5Y NB cells. | Cell Death & Disease

Fig. 6: PRPF40B modulates NTRK2 splicing to regulate TRKB-FL expression during differentiation in SH-SY5Y NB cells.

From: Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity

Fig. 6: PRPF40B modulates NTRK2 splicing to regulate TRKB-FL expression during differentiation in SH-SY5Y NB cells.

A Schematic representation of BDNF signaling through TRKB-FL and TRKB-T1. B Western blot analysis of TRKB-FL and TRKB-T1 expression levels in control, RA, and RA/BDNF-treated WT and G2 cell lines. C Relative mRNA expression levels of total TRKβ, TRKβ-FL, and TRKβ-T1 in control, RA, and RA/BDNF-treated WT and G2 cell lines. D Relative mRNA expression levels of TRKβ-FL and TRKβ-T1, normalized to total TRKβ, in control, RA, and RA/BDNF-treated WT and G2 cell lines. Data represent the mean ± SEM from three to six independent experiments. Statistical significance: *p ≤ 0.05, **p ≤ 0.01, and ****p ≤ 0.0001.

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