Fig. 3: The SOCS3/JAK2/STAT3 pathway is the downstream pathway of NSUN2.
From: NSUN2-mediated m5C modification of SOCS3 mRNA modulates macrophage polarization in bladder cancer
A JAK2/STAT3 were downregulated, whereas SOCS3 was upregulated, in the siNSUN2 group. B SOCS3/JAK2/STAT3 expression was altered in both RAW264.7 and THP-1 cells. C KEGG pathway results revealed that JAK2/STAT3 were enriched in both the siNSUN2 group of RAW264.7 cells and the control group of THP-1 cells. D, E WB and PCR results confirmed that NSUN2 knockdown upregulated SOCS3 and downregulated JAK2/STAT3. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Statistics are presented as the means ± SDs of three independent experiments.
