Fig. 4: NSUN2 mediates the polarization of macrophages via the SOCS3/JAK2/STAT3 pathway.
From: NSUN2-mediated m5C modification of SOCS3 mRNA modulates macrophage polarization in bladder cancer
A, B The JAK2/STAT3 pathway in the siNSUN2 group was rescued after SOCS3 was also knocked down. C–E The expression of M1/M2-related mRNAs and proteins and the secretion of cytokines in the siNSUN2 group were rescued after SOCS3 was knocked down. The promotion of M1 polarization and reduction in M2 polarization were reversed in the siNSUN2-siSOCS3 group. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. n.s. stands for non-significant. Statistics are presented as the means ± SDs of three independent experiments.
