Fig. 8: Changes on the protein (blue arrows) and transcriptomic level (red arrows) affecting the cellular mechanism related to the ferroptotic pathway.
From: Ferroptosis inhibition protects against α-synuclein-related neuronal cell death
Iron metabolism (left), cysteine and glutathione metabolism (top right), and polyunsaturated fatty acid metabolism (bottom right). ACSL4; Long-chain-fatty acid—CoA ligase 4, ACSL5; acyl-CoA synthetase long chain family member 5, AKR1C1; aldo-keto reductase family 1 member C1, AKR1C3; aldo-keto reductase family 1 member C3, CHMP5; charged multivesicular body protein 5, Cu; Copper, CYCS; cytochrome c, DHODH; dihydroorotate dehydrogenase, mitochondrial enzyme, DPP4; dipeptidyl peptidase 4, Fe2+; ferrous iron, Fe3+; Ferric iron, Fpn; Ferroportin, GPX4; glutathione peroxidase 4, GSH; glutathione (reduced glutathione form), GS-SG; glutathione disulfide (oxidized glutathione form), HMOX1; heme oxygenase 1, LOX; lipoxygenase, MAP1LC3; microtubule-associated protein 1 light chain 3, NCOA4; nuclear receptor co-activator 4, NOX; NADPH oxidase 4, PL-PUFA(PE)-OH; non-toxic polyunsaturated fatty-acids, PL-PUFA(PE)-OOH polyunsaturated fatty acid-containing-phospholipid hydroperoxides, ROS; reactive oxygen species, RSL3 (1S,3R)-RSL3, RTAs radical-trapping antioxidants, Se; Selenocysteine, SLC3A2; solute carrier family 3 member 2, SLC39A14; solute carrier family 39 member 14, SLC7A11; solute carrier family 7 member 11, STEAP3; metalloreductase. System XcT; glutamate/cystine antiporter system, TAX1BP1; Tax1 Binding Protein 1, TfR1; transferrin 1 receptor, TSKU; tsukushi, small leucine-rich proteoglycan, Ub; ubiquitin, VDAC2; voltage-dependent anion channel 2. Parts of the figure were made with the BioRender program.
