Fig. 2: Ablation of Chm resulted in apoptosis and decreased numbers of retinal neurons.
From: Deficiency disrupts photoreceptor viability and synaptic integrity in a choroideremia mouse model
A Retinal cross-sections of Chmfl/y and Chmfl/y; Six3-Cre mouse, stained for TUNEL (red) and DAPI (blue). B Quantitation of TUNEL+ cells in P30 Chmfl/y and Chmfl/y; Six3-Cre mouse retinas. Results are presented as the mean ± SEM (n = 5). C Quantitation of TUNEL positive cells in P30 Chmfl/y and Chmfl/y; Six3-Cre mouse retinas (n = 5). D Neuronal marker was used to recognize nerve distributions in retina layers, indicating the neuronal injury in Chmfl/y; Six3-Cre mouse. Scale bar: 30 μm. E Quantitation of cells that were immunoreactive for Neuronal marker in P30 Chmfl/y and Chmfl/y; Six3-Cre mouse retinas (n = 5). *P < 0.05, **P < 0.01, ***P < 0.001.
