Fig. 4: Up- and down–regulation of select gene clusters in Chmfl/y; Six3-Cre mouse.
From: Deficiency disrupts photoreceptor viability and synaptic integrity in a choroideremia mouse model
A–C Scatter plots and heat maps of differential gene expression profiles were compared by Spearman correlation coefficient (n = 3 for each group). A total of 1516 transcripts exhibited differential expression (downregulation, blue; upregulation, red) between Chmfl/y; Six3-Cre mouse, and littermate controls. D GO analysis evidenced decreases in gene clusters related to visual perception, detection of light stimulus, retina homeostasis, and phototransduction. Increases in gene clusters related to toll-like receptor signaling pathway, MAPK cascade, channel activity, Wnt signaling pathway, synaptic signaling, BMP signaling pathway, I-kappaB kinase/NF-kappaB signaling, and Ras protein signal transduction.
