Fig. 9: Targeting the Smad3/CISD2 axis inhibits bladder cancer growth in vivo by inducing ferroptosis. | Cell Death & Disease

Fig. 9: Targeting the Smad3/CISD2 axis inhibits bladder cancer growth in vivo by inducing ferroptosis.

From: Targeting the SMAD3/CISD2 axis suppresses bladder cancer progression by promoting ferroptosis in mesenchymal-like bladder cancer cells

Fig. 9

A–C RT-qPCR and western blot analyses validating the stable silencing efficiency of Smad3. D Schematic diagram of the experimental design for the animal model. E Representative images of subcutaneous tumors. F Photographs of xenograft tumors in nude mice. G Tumor growth curves in the xenograft model. H Comparison of subcutaneous tumor weights. I IHC staining of Smad3, CISD2, 4-HNE, GPX4, and Ki-67 in xenograft tumors. Data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; ns, not significant (p > 0.05).

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