Fig. 3: Single-cell RNA sequencing analysis of LUAD data reveals a consistent elevation of MRPL17 expression in malignant epithelial cells observed across primary tumor sites and various metastatic locations. | Cell Death & Disease

Fig. 3: Single-cell RNA sequencing analysis of LUAD data reveals a consistent elevation of MRPL17 expression in malignant epithelial cells observed across primary tumor sites and various metastatic locations.

From: MRPL17 is a critical regulator of mitochondrial function and a novel therapeutic target in non-small cell lung cancer

Fig. 3

UMAP visualization of the primary LUAD tumor, illustrating its cellular composition by distinct cell types (A). A dot plot detailing the percentage of cells expressing MRPL17 and their average expression levels across various primary tumor cell types, stratified by ‘normal,’ ‘early,’ and ‘advanced’ disease stages as contextualized by the original study (B). UMAP visualization of LUAD brain metastases (mBrain), depicting the distribution of various cell populations (C). A dot plot quantifying MRPL17 expression within the specific cell types identified in brain metastases (D). UMAP visualization of LUAD lymph node metastasis (mLN), showing its cellular landscape (E). A dot plot presenting MRPL17 expression within cell types found in lymph node metastasis, differentiating between non-lymph node (nLN) and metastatic lymph node (mLN) compartments (F). UMAP visualization of LUAD pleural effusion (PE), revealing its constituent cell types (G). A dot plot displaying MRPL17 expression levels across the cellular subsets identified within pleural effusion samples (H).

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