Fig. 1: SERPINB3 is overexpressed in human LUAD and LUSC and associates with poor prognosis in LUAD.
From: SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3’s activity and promotes lung tumorigenesis
Box plots comparison of the SERPINB3 expression levels between non-tumor (NT) and tumor (T) tissues of LUAD samples (A) and LUSC samples (B) from the TCGA database. TCGA: The Cancer Genome Atlas, FPKM: fragments per kilobase of transcript per million fragments. The statistical significance was determined by Wilcoxon rank-sum test. *p < 0.05, ***p < 0.001. Kaplan-Meier survival curves of overall survival (C) and disease-free survival (D) for LUAD patients from the TCGA cohort stratified by upper quartile (high) and lower quartile (low) of SERPINB3 expression levels. The statistical significance was determined by log-rank test. *p < 0.05. Kaplan-Meier survival curves of overall survival (E) (n.s.: no significance) and disease-free survival (F) (***p < 0.001) for LUSC patients from the TCGA cohort stratified by upper quartile (high) and lower quartile (low) of SERPINB3 expression levels. The statistical significance was determined by log-rank test.
