Fig. 7: SPOP blocks the inhibition of LZTS2 on CRC cell migration and proliferation.
From: SPOP and HAUSP bidirectionally regulate LZTS2 ubiquitination to modulate the Wnt pathway
A EdU incorporation assay showed that SPOP co-expression could restore LZTS2-suppressed HCT-116 cell proliferation. Quantitative analysis was shown on the right. The colony formation assays showed the proliferation of HCT-116 (B) and HT-29 cells (C) expressing indicated constructs. Quantitative analyses were shown on the right. The migrative abilities of HCT-116 (D) and HT-29 cells (E) transfected with the specified constructs were assessed by transwell assays. The expressions of constructs were examined by immunoblotting. Quantitative analyses were shown on the right.
