Fig. 10: A hypothetical model of USP8 regulated Hippo signaling mechanism and the positive feedback loop between USP8 and YAP in TNBC. | Cell Death & Disease

Fig. 10: A hypothetical model of USP8 regulated Hippo signaling mechanism and the positive feedback loop between USP8 and YAP in TNBC.

From: Positive feedback regulation between USP8 and Hippo/YAP axis drives triple-negative breast cancer progression

Fig. 10

The activation of USP8 enhances Hippo signaling activity and promotes the progression of breast cancer by deubiquitinating YAP K48 poly-ubiquitination. Furthermore, YAP is capable of inducing USP8 expression, which points to a positive feedback loop with Hippo signaling.

Back to article page