Table 1 The regulatory mechanism of pyroptosis by nuclear proteins.
From: Organelles and cancer cell pyroptosis: overview and perspectives
Target | Mechanism | Cancer Model | Cell lines | Ref. |
|---|---|---|---|---|
NF-κB | NF-κB/Caspase-3(8)/GSDME axis activation | Human gastric cancer | BGC823/DDP, SGC7901/DDP | [38] |
NF-κB/NLRP3/Caspase-1/GSDMD pathway activation | NSCLC | H1703, PC9 | [25] | |
BRD4 | BRD4-NLRP3/GSDMD complex potentiation | Colorectal cancer | SW620, LS174T, HCT116, DLD1 | [44] |
SIRT1 | AMPK/SIRT1/NF-κB signaling axis amplification | General tumor models | HepG2, MCF-7, HCT-15, HT-29 | [26] |
ATF4 | PERK/ATF4-dependent pyroptotic activation | Oral squamous cell carcinoma | CAL27, SCC-7 | [10] |
NRF2 | NRF2/ROS/TXNIP/NLRP3 cascade initiation | Esophageal squamous carcinoma | KYSE-30 | [19] |
NRF2 nuclear exclusion → NLRP3/caspase-1↑ | Colorectal cancer | HT29 | [21] | |
HMGB1 | HMGB1/RAGE pathway-mediated pyroptosis | Lung cancer | A549, H1299 | [45] |
