Table 2 Regulatory roles of membraneless organelles in pyroptosis and therapeutic implications.
From: Organelles and cancer cell pyroptosis: overview and perspectives
Organelles | Key Elements | Mechanism of Action | Therapeutic Targets | Ref. |
|---|---|---|---|---|
Stress Granules | DDX3X | Sequesters DDX3X to limit NLRP3 inflammasome activation | SG disassembly agents; DDX3X mutants | |
Centrosome | NEK7 kinase | Microtubule-mediated NLRP3 trafficking for inflammasome assembly | NEK7 stabilizers; Recombinant NEK7 delivery | |
Nuclear Speckles | MALAT1/SERPINB6B | SERPINB6B inhibits GSDMD cleavage via MALAT1 upregulation | MALAT1 ASOs; SERPINB6B CRISPRi | [181] |
