Fig. 3: Elevated INTS13 expression in surgically-treated cervical cancer tissues and various cervical cancer cell types.

INTS13 mRNA expression in human cervical cancer tissues (“T”) compared to adjacent paracancerous cervical tissues (“N”) (n = 20) (A). Representative Western blot showing INTS13 and HPV 16/18 E6 protein levels in five pairs of cervical cancer tissues (“T1”–“T5”) and paracancerous cervical tissues (“N1”–“N5”) (B). Quantitative densitometric analysis of INTS13 protein expression in all twenty pairs of cervical cancer and peritumoral tissues (C). INTS13 mRNA and protein levels, respectively, in primary cervical cancer cells (pCCa-1, pCCa-2, pCCa-3) compared to primary human cervical epithelial cells (priCEpi-1) (D, E). Data are presented as mean ± standard deviation (SD) with n = 5 replicates. Asterisks (*) indicate statistically significant differences (P < 0.05) compared to the “N” tissues or priCEpi-1 cells. The experiments were independently replicated five times with consistent results.