Fig. 8: Schematic illustration of the current study. | Cell Death & Disease

Fig. 8: Schematic illustration of the current study.

From: EIF4B Ser93 phosphorylation by ERK2 promotes epithelial-mesenchymal transition to drive colorectal cancer metastasis

Fig. 8: Schematic illustration of the current study.

EIF4B Ser93 phosphorylation by ERK2 promotes mesenchymal markers translation to drive CRC metastasis, while inhibition of ERK2 by Vx-11e suppresses eIF4B phosphorylation at Ser93 site and facilitates eIF4B degradation by ubiquitination, and thus inhibiting EMT and tumor metastasis (Created with BioRender. com).

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