Fig. 1: RPL5 is highly expressed in AML. | Cell Death & Disease

Fig. 1: RPL5 is highly expressed in AML.

From: RPL5 deficiency-induced ribosomal stress targets a select subset of proteins and inhibits the PI3K-Akt-mTOR signaling pathway to eradicate leukemia stem cells

Fig. 1: RPL5 is highly expressed in AML.

A Levels of RPL5 mRNA in BM MNC from pediatric AML (n = 54) and age-matched normal controls (n = 4). B Levels of RPL5 mRNA in PB (n = 19) and BM (n = 501) based on different karyotypes from adult AML and age-matched normal controls (n = 10 and n = 73, respectively). C Levels of RPL5 mRNA in BM MNC of AML patients (n = 74) and age-matched normal controls (n = 14) of WMU-Cohort. Summarized bar-graph (D) and representative WB picture (E) of RPL5 protein levels in AML cell lines compared with BM MNC from healthy controls. F Representative confocal pictures of RPL5 expression in BM MNC from normal controls, patients, and cell lines. (*** P < 0.001, **** P < 0.0001).

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