Fig. 2: RPL5 is required for AML cell survival. | Cell Death & Disease

Fig. 2: RPL5 is required for AML cell survival.

From: RPL5 deficiency-induced ribosomal stress targets a select subset of proteins and inhibits the PI3K-Akt-mTOR signaling pathway to eradicate leukemia stem cells

Fig. 2: RPL5 is required for AML cell survival.

A Cell growth of AML cells expressing shNC or shRPL5 was measured using the CCK8 assay (n = 3/group). B Representative figure of Annexin V+ cells in AML cells expressing shNC or shRPL5. C Representative figure and flow cytometric analysis of EdU+ cells in AML cells expressing shNC or shRPL5. D Analysis and representative figures of colonies produced by AML cells expressing shNC or shRPL5 (n = 3/group). E Schematic picture of the cell-derived xenografted model. F Representative figure and flow cytometric analysis of hCD45+ engraftment in PB of recipient mice xenografted with MOLM-13 cells expressing shNC or shRPL5 (n = 5/group). G Kaplan-Meier curve of recipient mice xenografted with MOLM-13 cells expressing shNC or shRPL5 (n = 6/group). (***P < 0.001, ****P < 0.0001).

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