Fig. 3: RPL5-deficiency hinders AML progression in the murine model. | Cell Death & Disease

Fig. 3: RPL5-deficiency hinders AML progression in the murine model.

From: RPL5 deficiency-induced ribosomal stress targets a select subset of proteins and inhibits the PI3K-Akt-mTOR signaling pathway to eradicate leukemia stem cells

Fig. 3: RPL5-deficiency hinders AML progression in the murine model.

A Schematic figure of MLL-AF9-transformed AML murine model. B Flow cytometric analysis and representative picture of GFP+ AML cells engraftment in PB of secondary recipients expressing shNC or shRpl5 (n = 4). Wright-Giemsa staining of AML blast in PB (C) and BM (D) of secondary recipients expressing shNC or shRpl5. E Cell counting analysis of Wright-Giemsa-stained AML blast in BM of secondary recipients expressing shNC or shRpl5 (n = 4/group). F The weight and representative picture of liver and spleen from secondary recipients expressing shNC or shRpl5 (n = 4/group). G The H&E stain of the liver and spleen slides of secondary recipients expressing shNC or shRpl5. H Kaplan-Meier curve of recipient mice engrafted with AMLMLL-AF9 cells expressing shNC or shRpl5 (n = 9 mice/group). (**P < 0.01, *** P < 0.001, **** P < 0.0001).

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