Fig. 6: RPL5 deficiency activates ribosomal stress-surveillance. | Cell Death & Disease

Fig. 6: RPL5 deficiency activates ribosomal stress-surveillance.

From: RPL5 deficiency-induced ribosomal stress targets a select subset of proteins and inhibits the PI3K-Akt-mTOR signaling pathway to eradicate leukemia stem cells

Fig. 6: RPL5 deficiency activates ribosomal stress-surveillance.

A Levels of RPL5 mRNA in mature cells and CD34+ cells from PB (n = 10 vs. n = 10) or BM (n = 10 vs. n = 8) of healthy volunteers. B Levels of RPL5 mRNA in CD34+ cells from AML patients (n = 13) and age-matched normal controls (n = 6) of WMU-Cohort. C Path-act-network analysis of RNA-seq data. D Subcellular location of differentially expressed gene in proteomics. E KEGG pathway analysis of RPL5 based on the TCGA-LAML database. F Protein levels of Akt, p-Akt, mTOR, and p-mTOR in the BM of AML mice expressing shNC or shRpl5. G Protein levels of Akt and p-Akt in AML cells treated with Anisomycin. H The analysis of apoptotic LIC treated with the indicated dose of rapamycin (n = 3/group). (*P < 0.05, ***P < 0.001, ****P < 0.0001).

Back to article page