Fig. 1: GNG4 expression is upregulated and associated with more aggressive grade type in prostate cancer. | Cell Death & Disease

Fig. 1: GNG4 expression is upregulated and associated with more aggressive grade type in prostate cancer.

From: Targeting GNG4 inhibits tumor progression and restores enzalutamide sensitivity in prostate cancer by suppressing autophagy

Fig. 1: GNG4 expression is upregulated and associated with more aggressive grade type in prostate cancer.

A Scatter plot showing the comparison of the GNG4 expression in normal prostate tissues and primary tumor tissues from the TCGA-PRAD dataset (normal [n = 100], tumor [n = 496]). B Waterfall diagram showing the immunohistochemistry staining H-score of GNG4 in prostate tumors and association with tumor grade. C Quantification bar chart of GNG4 Low and GNG4 High staining in indicated grade prostate cancer tissues (Grade I [n = 19], II [n = 40], III [n = 20], IV [n = 6], V [n = 5]). D Representative immunohistochemistry staining photographs of GNG4 in paracancerous tissue and various grade prostate cancer tissue (Scale bar, 200μm, 60μm). E qPCR analysis of GNG4 relative mRNA expression in prostate cancer cell lines and benign prostate hyperplasia cell. F Bar plot showing the gene set enrichment analysis of Hallmark and KEGG pathway collection in GNG4 high-expression group from TCGA-PRAD database. G Gene set enrichment analysis positively enriched in DU145 cells transcriptome sequencing (shCtrl vs. shGNG4). Results are listed by normalized enrichment score.

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