Fig. 2: 13C6-Glucose time-course tracing analysis highlights glycolysis and TCA impairments in AT cells. | Cell Death & Disease

Fig. 2: 13C6-Glucose time-course tracing analysis highlights glycolysis and TCA impairments in AT cells.

From: Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia Telangiectasia

Fig. 2: 13C6-Glucose time-course tracing analysis highlights glycolysis and TCA impairments in AT cells.

Mass isotopomer distributions (MID) for each intermediate indicated in the graph in low passage CTRL and AT fibroblast cells exposed to U-13C6-glucose 24–36 h after plating. M0, M2, M3, M4, M5, M6, M7, and M24 indicate the different masses of the isotopomers detected, and the number after M indicates the number of carbons derived from U-13C6-glucose administered to CTRL and AT cells (M0 represents no labeled carbons). The different time points (2, 4, and 24 h) are indicated in the figure. Statistical analysis was conducted using an unpaired t-test. *P < 0.05; **P < 0.01; ***P < 0.001. N = 5 for CTRL and N = 6 for AT cells. See “Materials and methods” for more details.

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