Fig. 5: Inhibition of UHRF1 demonstrates potential therapeutic value in the treatment of advanced prostate cancer. | Cell Death & Disease

Fig. 5: Inhibition of UHRF1 demonstrates potential therapeutic value in the treatment of advanced prostate cancer.

From: UHRF1 regulates AR ubiquitination to promote the loss of AR signaling and enzalutamide resistance in progression of prostate cancer

Fig. 5: Inhibition of UHRF1 demonstrates potential therapeutic value in the treatment of advanced prostate cancer.

A Representative images of tumors derived from NC- and UHRF-knockdown cells. B Growth curves of cell-derived xenografts (CDX) in tumors derived from NC and UHRF1 knockdown cells. C Immunohistochemical staining of UHRF1, and Ki67 in tumor tissues derived from NC and UHRF1 knockdown cells. D Proposed model: UHRF1 promotes the ubiquitination of AR, thereby facilitating its degradation and promoting cancer cell proliferation through AR-independent compensatory mechanisms, thus contributing to tumor treatment resistance.

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