Fig. 8: Simvastatin rescues the phenotypes induced by RTN3 knockout. | Cell Death & Disease

Fig. 8: Simvastatin rescues the phenotypes induced by RTN3 knockout.

From: Declined RTN3 stabilizes DHCR7 to induce cholesterol-dependent tumor progression and MEK inhibitors insensitivity in thyroid cancer

Fig. 8: Simvastatin rescues the phenotypes induced by RTN3 knockout.The alternative text for this image may have been generated using AI.

A, B siDHCR7 (A) and Simvastatin (B) rescued insensitivity to Mirdametinib caused by RTN3 KO. n = 3. C, D Tumor volume (C) and growth curve (measured every 2 days) (D) of xenograft tumors. E, F Representative images (E) (scale bar, 100 μm) and quantification (F) of IHC staining of RTN3 and Ki-67. n = 5. *: P < 0.05, ****: P < 0.0001, ns: P ≥ 0.05.

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