Fig. 4: Hypoxia-mediated SNPH down-regulation promotes lamellipodia formation and metastasis of CRC cells. | Cell Death & Disease

Fig. 4: Hypoxia-mediated SNPH down-regulation promotes lamellipodia formation and metastasis of CRC cells.

From: HIF-1α suppresses SNPH expression to facilitate liver metastasis of colorectal cancer through regulating mitochondrial dynamics and filopodia formation

Fig. 4: Hypoxia-mediated SNPH down-regulation promotes lamellipodia formation and metastasis of CRC cells.

A–D Transwell migration and invasion analysis for stably transfected CRC cells with treatment as indicated. E Representative images of IF staining for SNPH (green) and mitochondria (Mito-tracker-red) in CRC cells with different treatments as indicated. Scale bars, 5 µM. F, G Average length and area of mitochondria per cell were analyzed in CRC cells with treatment as indicated in (E). H, I Phalloidin staining in CRC cells as indicated. Triangles indicate lamellipodia formation. Scale bars, 5 µM. J Migration tracks of individual cells in RKO, as indicated, were shown as a spider plot. *P < 0.05; **P < 0.01; ***P < 0.001.

Back to article page