Fig. 3: Spatial distribution of HNRNPH1 expression.
From: HNRNPH1 drives glioblastoma progression by regulating the splicing of cell cycle genes
A Heatmap of the expression levels (RNA-seq) of HNRNPH1 and cell cycle-associated genes in different anatomical regions of GBM. B Two-dimensional visualization of cellular states. Each color corresponds to one cellular state: AC-like (red), MES-like (green), NPC-like (light blue), and OPC-like (purple). The position of the dots reflects their relative scores for the meta-modules. C Box plot of HNRNPH1 expression (normalized counts) between AC-like (red), MES-like (green), NPC-like (light blue), and OPC-like (purple). Data were analyzed by the Wilcoxon test (n = 6863). D Spatial map of sample UKF313 showing spot annotation by MP. Shown are the mesenchymal-hypoxia (red) and the proliferative (blue) MPs. E Spatial map of HNRNPH1 expression in sample UKF313. F Density plots of HNRNPH1 expression in mesenchymal-hypoxia (red) and proliferative (blue) MPs using normalized read count data (n = 10767 spots across 26 GBM sections). G, H Spatial map of HNRNPH1 expression (red) and VEGFA expression (green, G) or AURKB expression (green, H) in sample UKF255.
