Fig. 7: A mechanism schematic diagram of tRF-Ser-mediated tumor suppression in GC. | Cell Death & Disease

Fig. 7: A mechanism schematic diagram of tRF-Ser-mediated tumor suppression in GC.

From: A new candidate tumor suppressor tRF-Ser inhibits gastric cancer progression by regulating the CNBP/HSPA8 axis

Fig. 7: A mechanism schematic diagram of tRF-Ser-mediated tumor suppression in GC.

tRF-Ser binds to the transcription factor CNBP and promotes its accumulation in the cytoplasm, thereby repressing CNBP-mediated transcriptional activation of HSPA8. Then, the tRF-Ser/CNBP/HSPA8 axis suppresses β-catenin-mediated EMT and induces GPX4 ubiquitination-dependent ferroptosis to inhibit GC progression.

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