Fig. 1: Analysis results of scRNA-seq combined with ST. | Cell Death & Disease

Fig. 1: Analysis results of scRNA-seq combined with ST.

From: The RASSF1C-HIF-1α axis drives macrophage lipid metabolism to promote pancreatic cancer

Fig. 1: Analysis results of scRNA-seq combined with ST.The alternative text for this image may have been generated using AI.

A, B t-SNE plots showing cell distribution differences between the KPC model (PAAD) and normal pancreatic tissue. A Grouped by tissue type. B Grouped by experimental groups. C t-SNE plot annotated with six major cell types: endothelial cells, epithelial cells (cancer cells), macrophages (TAMs), fibroblasts, B cells, and T cells. D Proportional distribution of different cell types in KPC and normal tissues. E Flowchart of combined analysis of scRNA-seq and ST; F ST results showing the spatial distribution of cell types in four KPC samples. G Network graph of cell interactions, with red lines indicating interaction strength. H Heatmap of cell proportion correlation, displaying correlations between cell types. t-SNE plot (I) and a bar graph (J) show the macrophage subtypes’ distribution.

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