Fig. 6: Lactate-activated macrophages influence PAAD cell migration and invasion through IRF7. | Cell Death & Disease

Fig. 6: Lactate-activated macrophages influence PAAD cell migration and invasion through IRF7.

From: The RASSF1C-HIF-1α axis drives macrophage lipid metabolism to promote pancreatic cancer

Fig. 6: Lactate-activated macrophages influence PAAD cell migration and invasion through IRF7.The alternative text for this image may have been generated using AI.

A Changes in IRF7 expression in THP-1 and Raw264.7 macrophages after hypoxia or lactate treatment. B Effect of lactate on IRF7 expression in macrophages. C Influence of lactate on M2 marker expression in macrophages. D Influence of lactate on M1 marker expression in macrophages. E Schematic of various pre-treated macrophages and their CM impacting PAAD cells. F, G Transwell assays showing the effects of macrophage-CM on PAAD cell migration and invasion (scale bar = 50 µm). All cell-based experiments were performed with three independent biological replicates. Data are presented as mean ± SD with individual data points overlaid; *p < 0.05, **p < 0.01, ***p < 0.001.

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