Fig. 1: Glucose metabolism in activated CD8 T cells under JAK inhibition. | Cell Death & Disease

Fig. 1: Glucose metabolism in activated CD8 T cells under JAK inhibition.

From: Disruption of metabolic licensing by JAK inhibitors constrains CD8 T cell activation and effector function

Fig. 1: Glucose metabolism in activated CD8 T cells under JAK inhibition.

Naïve and memory CD8 T cells from healthy donors (HD) were polyclonally activated (Act) for 3 days in the presence or absence of JAK1/3i, JAK1i, or JAK1/2i. Cells without stimulation were used as a control (Non-Act). A, B Representative histograms of 2-NBDG uptake and GLUT1 expression. C, D Correlation between the frequency of 2-NBDG⁺ and GLUT1⁺ cells in naive (C) and memory (D) CD8 T cells. Each bubble colour denotes a different experimental condition. Pearson correlation coefficients (r) and P values are indicated. E, F Lactate concentration (mmol/L) (E) and glucose levels (g/L) (F) measured in culture supernatants. Data are shown as mean ± SD from samples of 9 individual HD assayed across three independent experiments. P values were calculated using paired t test (E, F).

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