Fig. 8: Schematic model on EHMT2-MBLAC2 signaling axis in rDNA DSB-induced transcriptional silencing and tumorigenesis. | Cell Death & Disease

Fig. 8: Schematic model on EHMT2-MBLAC2 signaling axis in rDNA DSB-induced transcriptional silencing and tumorigenesis.

From: The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damage

Fig. 8: Schematic model on EHMT2-MBLAC2 signaling axis in rDNA DSB-induced transcriptional silencing and tumorigenesis.

EHMT2 suppresses rDNA transcription by either targeting MBLAC2 or regulating deposition of H3K9me2 at chromatin upon rDNA DSBs induction. The EHMT2-MBLAC2 signaling axis promotes rDNA DSB repair, maintains rDNA stability and cell DSB tolerance in response to rDNA breaks. Additionally, DYRK1B facilitates EHMT2 accumulation at nucleolar caps. Inhibition of EHMT2-MBLAC2 axis compromised nucleolar responses, especially rDNA DSB-induced transcriptional silencing and cell viability, shedding light on the importance of rDNA instability in tumorigenesis.

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