Fig. 2: PKD2 knockdown slowed down the rise time kinetics and decay time kinetics of developed force. | Cell Death & Disease

Fig. 2: PKD2 knockdown slowed down the rise time kinetics and decay time kinetics of developed force.

From: Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips

Fig. 2: PKD2 knockdown slowed down the rise time kinetics and decay time kinetics of developed force.The alternative text for this image may have been generated using AI.

Data summary showing that PKD2 knockdown with Ad-PKD2-shRNA1 reduced the passive tension (A) and total tension (B) at different electrical pacing frequencies. Data summary showing that PKD2 knockdown with Ad-PKD2-shRNA1 prolonged the rise time 90 (C) and decay time 90 (D), and decreased the maximal rise slope (E) and maximal decay slope (F) at different pacing frequencies in H7-CMs-derived hvCTS. n = 7. Mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001.

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