Fig. 1: Slc7a5 ablation in Syn1-expressing neurons causes motor dysfunction at perinatal stage.
From: The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage
A Schematic diagram of generation of neuron-specific Slc7a5 knockout mice. B Kaplan–Meier survival analysis of Slc7a5fl/fl (n = 8) and Syn1-Cre;Slc7a5fl/fl mice (n = 12). C Schematic diagram of behavioral analyses in Slc7a5fl/fl and Syn1-Cre;Slc7a5fl/fl mice. D Body weight of Slc7a5fl/fl (1 week: n = 20; 2 week: n = 22) and Syn1-Cre;Slc7a5fl/fl mice (1 week: n = 7; 2 week: n = 10). E–G Quantitative data of hindlimb suspension test; (E) latency to fall (seconds), (F) number of pulls, and (G) hindlimb score of Slc7a5fl/fl (1 week and 2 week: n = 20) and Syn1-Cre;Slc7a5fl/fl mice (1 week and 2 week: n = 7). Solid bars represent the results of the first trial, while dashed bars represent the results of the second trial. H Quantitative data of negative geotaxis test; latency to upward (seconds) of Slc7a5fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5fl/fl mice (1 week: n = 7; 2 week: n = 9). I–K Representative pictures and quantitative data of tail suspension test (self-clasping test); (J) clasping time (seconds), and (K) clasping score of Slc7a5fl/fl (1 week: n = 11; 2 week: n = 21) and Syn1-Cre;Slc7a5fl/fl mice (1 week: n = 7; 2 week: n = 8). L Quantitative data of righting reflex test; latency to right (seconds) of Slc7a5fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5fl/fl mice (1 week: n = 7; 2 week: n = 9). NS not significant. *P < 0.05, **P < 0.01, and ***P < 0.001.
