Fig. 3: Slc7a5 ablation in Syn1-expressing neuron results in gliosis and myelopathy in lumbar spinal cord.
From: The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage
A–C Immunofluorescent images and quantitative data of GFAP staining in lumbar spinal cord; (B) the number of GFAP positive cell (/mm2), and (C) GFAP immunointensity of Slc7a5fl/fl (n = 3) and Syn1-Cre;Slc7a5fl/fl mice (n = 3) at 2 weeks of age. Arrowheads indicate representative GFAP-positive cells. D–F Immunofluorescent images and quantitative data of MAG staining in lumbar spinal cord; (E) the number of MAG positive cell (/mm2), and (F) MAG immunointensity of Slc7a5fl/fl (n = 3) and Syn1-Cre;Slc7a5fl/fl mice (n = 3) at 2 weeks of age. G–I Immunofluorescent images and quantitative data of Iba1 staining in lumbar spinal cord; (H) the number of Iba1 positive cell (/mm2), and (I) Iba1 immunointensity of Slc7a5fl/fl (n = 3) and Syn1-Cre;Slc7a5fl/fl mice (n = 3) at 2 weeks of age. Arrowheads indicate representative Iba1 positive cells. NS not significant, GM gray matter, WH white matter. *P < 0.05 and **P < 0.01.
