Fig. 3: Effects of compound #2714 on inducing apoptosis in LL/2 cells, as analyzed by flow cytometry in vitro. | Cell Death Discovery

Fig. 3: Effects of compound #2714 on inducing apoptosis in LL/2 cells, as analyzed by flow cytometry in vitro.

From: #2714, a novel active inhibitor with potent G2/M phase arrest and antitumor efficacy in preclinical models

Fig. 3

a The morphological changes and apoptosis induction, concentration-dependent effects, were measured after Lewis lung carcinoma (LL/2) cells were treated with compound #2714 for 48 h and stained with propidium iodide (PI). b The effects of #2714 on mitochondrial membrane potential (ΔΨm) were detected using Rho 123 staining after LL/2 cells were treated with #2714 for 48 h. c The histogram graphs and data shown are representative of three parallel and independent experiments (mean ± SD, n = 3; *p < 0.05; **p < 0.01)

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