Table 1 The effects of compound #2714 on cancer and non-cancer cellular viability

From: #2714, a novel active inhibitor with potent G2/M phase arrest and antitumor efficacy in preclinical models

Cell line

Cell line type

IC50 (μM)

LL/2

Murine lewis lung carcinoma cell

5.43

4T1

Mouse mammary carcinoma cell

6.12

NIH-3T3

Mouse fibroblasts cell

å 40

HK-2

Human proximal tubular cell

å 40

  1. A CCK-8 assay was carried out to measure the effects of #2714 on cell viability. All cell lines were exposed to different concentrations (cancer lines 0–20 μM; non-cancer lines 0–40 μM) of #2714 for 48 h. Data were expressed as mean of IC50; n = 3
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