Table 1 Top 15 genes with the negative correlation of DNA methylation and mRNA expression between NOA and OA

Probe name	Gene symbol	Gene ID	Reference accession	Region	ρ value	P value methylation	Q value methylation	Δβ value (NOA/OA)	Fold change (NOA/OA)
cg07085664	CHRNB3	1142	NM_000749	Body	−0.757	0.048	0.124	0.442	0.429
cg07421329	EFHA2	286097	NM_181723	Body	−0.757	0.048	0.124	−0.345	6.455
cg02134046	SPERT	220082	NM_152719	3′-UTR	−0.786	0.034	0.100	0.413	0.002
cg13823366	FBXO39	162517	NM_153230	TSS1500	−0.786	0.034	0.100	0.387	0.003
cg00601486	H1FNT	341567	NM_181788	1st Exon	−0.786	0.034	0.100	0.504	0.005
cg24153003	OAZ3	51686	NM_001134939	Body	−0.786	0.034	0.100	0.213	0.005
cg27623334	CXorf61	203413	NM_001017978	TSS200	−0.786	0.034	0.100	0.544	0.006
cg13513349	ADAM29	11086	NM_001130704	5′-UTR	−0.786	0.034	0.100	0.445	0.007
cg15822411	CCDC83	220047	NM_173556	1st Exon	−0.786	0.034	0.100	0.310	0.009
cg09848324	PDCL2	132954	NM_152401	Body	−0.786	0.034	0.100	0.514	0.009
cg26647524	KBTBD5	131377	NM_152393	TSS200	−0.786	0.034	0.100	0.418	0.010
cg23478805	*ZCCHC13*	389874	NM_203303	TSS200	−0.786	0.034	0.100	0.572	0.010
cg22806002	BTG4	54766	NM_017589	TSS200	−0.786	0.034	0.100	0.218	0.011
cg04864648	PDHA2	5161	NM_005390	TSS200	−0.786	0.034	0.100	0.492	0.012
cg24803912	POU5F2	134187	NM_153216	TSS200	−0.786	0.034	0.100	0.465	0.012

NOA non-obstructive azoospermia, OA obstructive azoospermia
Bold values indicated that DNA methylation and mRNA expression of ZCCHC13 was highly anticorrelated and was ranked very top

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