Fig. 2: NOS2 deletion inhibits lung epithelial cell hyperproliferation, fibrosis, and inflammatory responses. | Cell Death Discovery

Fig. 2: NOS2 deletion inhibits lung epithelial cell hyperproliferation, fibrosis, and inflammatory responses.

From: Macrophage inducible nitric oxide synthase circulates inflammation and promotes lung carcinogenesis

Fig. 2: NOS2 deletion inhibits lung epithelial cell hyperproliferation, fibrosis, and inflammatory responses.

a Analysis of Ki67-positive epithelial cells in basal cells of lung bronchi in WT, KA/KA, and KA/KA;Nos2−/− mice, examined by IHC staining and statistically analyzed by Student’s t-test. Data represent mean ± SD (n = 3/group, 500 cells were counted in each group). *p < 0.05; ***p < 0.001. b Chemical Masson’s trichrome staining in the lungs of WT, KA/KA, and KA/KA;Nos2−/− mice at 5 months of age. Blue color, positive staining. Scale bar, 50 μm. c Heat maps show gene expression profiles between KA/KA and KA/KA;Nos2−/− lungs from mice at 5 months of age. All the groups between KA/KA and KA/KA;Nos2−/− lungs were statistically analyzed by an ANOVA one-way test. Each p-value for all groups, p < 0.05

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