Fig. 6: NOS2 regulates macrophage properties and NOS2 null bone marrow (BM) transplantation reduces lung SCC development.
From: Macrophage inducible nitric oxide synthase circulates inflammation and promotes lung carcinogenesis
a Comparison of the expression of multiple cytokines in KA/KA vs. WT macrophages or KA/KA;Nos2−/− vs. WT macrophages, as detected by RT2 2 Profile PCR Array. Each group contains three samples. b Top panel: a scheme for BM transplant experiment. KA/KA or KA/KA;Nos2−/− BM was injected to irradiated KA/KA or KA/KA;Nos2−/− mice. Bottom panel: lung SCC incidence in different irradiated chimeric mice. Infiltrating macrophages (Mac) and lymphocytes (LymC) in the lungs of irradiated KA/KA mice receiving KA/KA BM were used as positive controls (++++). Infiltrating Mac and LymC in the lungs of irradiated WT mice receiving KA/KA BM were used as negative controls (−). Tumor incidence in irradiated KA/KA mice receiving KA/KA;Nos2−/− BM and in irradiated KA/KA;Nos2−/− mice receiving KA/KA BM was compared with the positive control. Data are analyzed by chi-square test
